Nitric Oxide Synthase Activity and Tumor Progression

نویسندگان

  • Christopher S. Rabender
  • Asim Alam
  • Gobalakrishnan Sundaresan
  • Robert J. Cardnell
  • Vasily A. Yakovlev
  • Nitai D. Mukhopadhyay
  • Paul Graves
  • Jamal Zweit
  • Ross B. Mikkelsen
چکیده

1 The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression Christopher S. Rabender, Asim Alam, Gobalakrishnan Sundaresan, Robert J. Cardnell, Vasily A. Yakovlev, Nitai D. Mukhopadhyay, Paul Graves, Jamal Zweit, Ross B. Mikkelsen Department of Radiation Oncology, Department of Radiology and Center for Molecular Imaging, Department of Biostatistics, Virginia Commonwealth University, Richmond VA 23298 USA Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson, Houston, Texas 77030 USA Department of Radiation Oncology, New York Methodist Hospital, Weill Cornell Medical College, Brooklyn, NY 11215 USA Running Title:Nitric Oxide Synthase Activity and Tumor Progression

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of inducible nitric oxide synthase activity in pancreatic islets of young and aged rats

Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...

متن کامل

Contribution of Nitric Oxide Synthase (NOS) Activity in Blood-Brain Barrier Disruption and Edema after Acute Ischemia/ Reperfusion in Aortic Coarctation-Induced Hypertensive Rats

Background: Nitric oxide synthase (NOS) activity is increased during hypertension and cerebral ischemia. NOS inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (BBB) disruption and cerebral edema formation during stroke in acute hypertension. Here, we investigated the role of NOS inhibition in progression of edema formation and BBB d...

متن کامل

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression.

The tumor suppressor gene product p53 plays an important role in the cellular response to DNA damage. DNA damage can lead to p53-mediated growth arrest and apoptosis. High concentrations of nitric oxide (NO) and NO metabolites such as peroxynitrite and NO2 cause DNA damage and have been shown to be mutagenic. Furthermore, NO induces p53 accumulation and, as part of a feedback loop, p53 mediates...

متن کامل

Inhibition of nitric oxide synthase activity improves focal cerebral damage induced by cerebral ischemia/reperfusion in normotensive rats

Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...

متن کامل

Effect of 17-? Estradiol on the Expression of Inducible Nitric oxide Synthase in Parent and Tamoxifen Resistant T47D Breast Cancer Cells

Indirect evidence suggests that estrogen is involved in the etiology of breast cancer. Estrogen is also thought to modulate nitric oxide (NO) in human breast tumor tissue via regulation of inducible nitric oxide synthase (iNOS). Objectives of this study were to determine whether estradiol (E2) affects iNOS expression level in breast cancer cells and to study the effect of various concentrations...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015